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Biomolecular Resource Facility
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Galveston, Texas 77555-0635

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  In the Lab  
Proteomics UTMB NHLBI Proteomics Center Serving as the home for one of seven newly awarded national Proteomics Centers funded by the NHLBI, the Biomolecular Resource Facility at UTMB brings the power of multiple analytical technologies to proteomics research. The UTMB NHLBI Center for Airway Inflammation consists of a multi-disciplinary team of scientists and physician-scientists to study protein expression associated with signaling pathways important in airway inflammation. In addition, the Center is engaged in the development of innovative technologies for application to proteomics research. It is the result of an NHLBI initiative to establish centers to enhance and develop innovative proteomics technologies and apply them to biological questions relevant to heart, lung, blood, and sleep health and disease.

ThermoFinnegan OrbiTrap Powerful suite of mass spectrometers The BRF has four mass spectrometers that significantly enhance our proteomics capabilities. Along with the AB Sciex 4800 and the new 5800 Proteomics Systems (MALDI TOF-TOF), the 4000 Q-Trap linear ion-trap with nano LC, and the ThermoFisher LTQ OrbiTrap Velos with nanoLC, we now have a suite of high powered, state-of-the-art mass spectrometers to address virtually any proteomics challenge.

  In the News

GenoLogics, developer of the proteomics laboratory information management system ProteusLIMS, reports the University of Texas Medical Branch (UTMB) as its most recent customer.
  Recent Publications

Toward the proteome of the human perpheral blood eosinophil Proteomics-Clin Appl 3, 1151-1173, 2010

Role of Peroxiredoxin-1 and -4 in Protection of RSV-induced Cysteinyl-oxidation of Nuclear Cytoskeletal Proteins J. Virology 84,9533-9545, 2010

UTMB awarded $10.9M for new research center - Houston Business Journal, October 11, 2008.

Spotlight: UTMB Biomolecular Resource Facility
Biochemistry & Molecular Biology Today
, May, 2007: Number 225.

Cross-Talk between ICAM-1 and Granulocyte-Macrophage Colony-Stimulating Factor Receptor Signaling Modulates Eosinophil Survival and Activation
J. Immunology 180, 4182-4190, 2008

Saturation Fluorescence Labeling of Proteins for Proteomic Analysis
Analytical Biochemistry 374, 250-262, 2008

Development of Sindbis Viruses Encoding nsP2/GFP Chimeric Proteins and Their Application for Studying nsP2 Functioning
J. of Virology 81, 5046, 2007

Proteomic Analysis of Hypoxia/Ischemia-Induced Alteration of Cortical Development and Dopamine Neurotransmission in Neonatal Rat
J. Proteome Research 5(9), 2396 - 2404, 2006

Functional Analysis of the Nuclear Proteome of Human A549 Alveolar Epithelial Cells by HPLC-High Resolution 2D Gel Electrophoresis

Proteomics 6, 2656-2672, 2006

The Joy and Pain of 2D Electrophoresis: An Overview - AES Newsletter
October, 2004: Volume 9, Issue 4

Thiol-reactive Dyes for Fluorescence Labeling of Proteomic Samples
Electrophoresis 24, 2348-2358, 2003



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