Dr. Abbey Berenson talks with new mother Ana Palacios, 24. Berenson, with the help of interpreter Irma Rabago, tells Palacios the HPV vaccine is 96 to 100 percent effective at preventing four strains of a virus that causes cervical cancer and genital warts.UTMB's Dr. Abbey Berenson has been awarded a $1.2 million grant to start a program that will provide a vaccination against cervical cancer to many low-income women who receive health care services at the medical branch.

Berenson, a physician who specializes in pediatric and adolescent gynecology, received the grant from the Cancer Prevention Research Institute of Texas.

According to the National Cancer Institute, cervical cancer affects nearly half a million women worldwide each year and kills more than 250,000.

Hispanic women have almost twice the risk of cervical cancer as white women. In 2006, the FDA approved an HPV vaccine that, when properly administered, is effective 96 to 100 percent against four virulent strains of the HPV virus — the main cause of cervical cancer and genital warts.

The complete vaccine series consists of three shots and is recommended for girls between 11 and 12, before sexual activity has commenced.

But even for women who already have become sexually active, the vaccination still is recommended for those up to 26. The recommended course of the vaccine, after the initial shot, is a second shot four to eight weeks later and a final shot four months after the second.

However, completion rates of this vaccine have been very low in many parts of Texas, including Galveston County.

A survey of low-income pregnant women from Galveston County who were seen at the medical branch indicated their HPV vaccination rates are far lower than those reported among the general population by the Centers for Disease Control.

Seventy percent of the low-income pregnant women the medical branch serves are Hispanic and thus at high risk for cervical cancer.

Reasons for the low inoculation rate among this population, according to Berenson, include a lack of awareness about the vaccine, limited access to vaccination sites and high cost.

Berenson’s grant project is designed to improve vaccination rates by addressing all three barriers. Galveston County women who receive prenatal care at medical branch clinics will receive information about the HPV vaccine during their pregnancy and again after they deliver.

Injections will be available on the postpartum ward, which will improve access. All costs will be covered by federal or state programs.

Berenson said she anticipates this change will allow the medical branch to provide the vaccination series to 900 postpartum women during two years.

Berenson is director of the medical branch’s Center for Interdisciplinary Research in Women’s Health and holds the Ruth Hartgraves Chair in Obstetrics and Gynecology.

Her research on the HPV vaccine, published in the journal Cancer, showed many women who begin the HPV vaccine do not return for the second or third dose.

This is a significant problem because fewer than three doses might not provide complete protection against cervical cancer.

To address the completion rate problem, she has developed a partnership with additional clinics that see the mothers and their babies for postpartum visits and infant vaccinations.

“These partnerships will allow us to coordinate the timing of their subsequent doses with their postpartum visits and their children’s visits to their pediatricians,” Berenson said.

“We anticipate that this prevention project will show that administering the HPV vaccination postpartum decreases barriers and that follow-up injections should be given at postpartum or infant visits.

“We feel certain this plan can provide a model for reducing the number of women who experience cervical cancer and its devastating consequences.”