Crucial muscle-building insulin response restored with a 45-minute walk

FOR IMMEDIATE RELEASE: MAY 30, 2007

GALVESTON, Texas - Why do older people tend to lose muscle mass and grow frail? One important factor identified by medical science is the reduced ability of the elderly to respond to the muscle-building stimulus of the hormone insulin.

Insulin is best known for its link to diabetes - a condition in which either a complete lack of insulin or systemic resistance to the hormone's activity (as in type 2 diabetes) causes blood sugar levels to soar out of control. Recent studies have shown, however, that insulin also provides crucial assistance in building muscle, and that its ability to do so drops off dramatically in the elderly.

Now, a small but provocative study by medical researchers in Texas and California suggests that a simple, cost-free therapy appears to largely overcome that drop-off in insulin response: moderate aerobic exercise such as walking.

Experiments at the University of Texas Medical Branch at Galveston (UTMB) and the University of Southern California, Los Angeles conducted on 13 healthy volunteers in their late 60s showed that 45 minutes of walking 20 hours before exposure to insulin restored the muscle-growth-stimulating effects of the hormone to levels comparable to those seen in normal young adults.

Prior research had suggested that a large part of the problem older people experience lies in the tiny blood vessels that feed the muscles protein-building amino acids, glucose and insulin (which itself also works within muscle cells as a powerful protein growth factor). In young adults, these normally closed vessels open wide in response to the insulin increase generated by a meal, providing clear passage for muscle-making materials. In elderly people, however, this process, known as "vasodilation," is much less pronounced.

"We thought, let's see what happens if we use aerobic exercise, one of the interventions that has been shown in the past to improve vasodilation, to find out whether we can get insulin to stimulate muscle synthesis in older people," said UTMB professor Elena Volpi, senior author of a paper on the experiments appearing in the June issue of the journal Diabetes. "It turned out that a fast walk restored the insulin response quite well."

To test their hypothesis, the researchers first required six of their 13 subjects to walk for 45 minutes on a treadmill quickly enough to keep their hearts beating at 70 percent of their maximum rate -the same aerobic intensity level recommended to maintain cardiovascular fitness. The other seven subjects simply rested.

On the following morning, the researchers sampled the blood going into and coming out of thigh muscle in each of the volunteers, while supplying via the femoral artery a concentration of insulin similar to that released after a typical meal. They also took three small muscle tissue samples from each subject.

Tracer techniques enabled the scientists to track amino acids (the building blocks of muscle proteins) and determine muscle-protein synthesis and breakdown rates from the blood and muscle samples, while measuring blood flow at the same time. These revealed that the volunteers who exercised had both higher blood flow and net muscle protein growth. In addition, the researchers screened the muscle biopsy samples for signals associated with insulin's ability to stimulate the assembly of muscle protein from amino acids. This test also showed that exercise boosted insulin's role as a muscle protein growth factor.

"We already know that moderate aerobic exercise reduces cardiovascular disease, improves glucose uptake, and improves endurance," Volpi said. "Now it looks like it may also slow the rate of muscle loss in aging. We need to test this hypothesis further with larger trials, but still, it's one more reason why elderly people ought to be regularly walking, swimming or cycling."

Other authors of the Diabetes paper are UTMB postdoctoral fellows Satoshi Fujita and Jerson Cadenas, associate professor Blake B. Rasmussen, physical therapy graduate students Micah J. Drummond and Erin L. Glynn, and USC-Los Angeles professor Fred R. Sattler.

This research was supported by two grants from the National Institute on Aging, including UTMB's National Institute on Aging-funded Claude D. Pepper Older Americans Independence Center; the Robert E. and May R. Wright Foundation; the National Institute for Arthritis and Musculoskeletal and Skin Diseases; and the NIH-funded General Clinical Research Centers at UTMB and USC.
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