Last week during the Vaccines for Biothreats and Emerging and Neglected Diseases Symposium, organized by UTMB’s Sealy Center for Vaccine Development, the Elsevier journal Vaccine released a supplement dedicated to vaccines for biodefense. This publication provides a comprehensive, state-of-the-art overview on vaccines that have been developed against a diverse group of human and veterinary pathogens. Guest co-editor is UTMB’s Alan Barrett.