Studies have shown that the offspring of mothers on a low-protein diet are more likely to develop hypertension as adults. Now, UTMB Drs. Haijun Gao, Uma Yallampalli and Chandra Yallampalli report that, in rats, the high maternal testosterone levels associated with a low-protein diet are caused by reduced activity of an enzyme that inactivates testosterone, allowing more testosterone to reach the fetus and increase the offspring's susceptibility to adulthood hypertension.